Aniko
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Question 21·Medium·Standard English Conventions

For centuries, artists have extracted bright pigments from insects: cochineal red, in particular, lent vibrant hues to Renaissance paintings. The dye had fallen out of favor by the mid-twentieth ______ sustainable-fashion designers have renewed interest in cochineal for its ecofriendly properties.

Which choice completes the text so that it conforms to the conventions of Standard English?